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Whenever you can, opt for generic drugs. According to the National Association of Chain Drug Stores the average cost is less than a third as much as their brand-name counterparts. For example, the drug mentioned in tip number 29, Zegerid, can cost over $4/pill as opposed to its generic form, Omeprazole, which can cost as low as .17 cents/pill; however, the generic equivalent may not be as effective as the branded OTC drug because it may have other fillers.
Remind your prescribing physician that you are interested in generic drugs if that is an option. This way, he can take that into consideration and avoid writing DAW (Draw As Dispensed), and have your pharmacist assist you with the generic equivalent.
You might still need to comparison shop to get the best price on generic drugs these days. Unfortunately, some major pharmacies do not pass on the discounts that they got on these generics to their customers.